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	Provedor de dados BJMBR (2) Autor Palma,B.D. (2) Tufik,S. (2) Bignotto,M. (1) Gabriel Jr.,A. (1) Hipolide,D.C. (1) Palavra-chave Autoradiography (1) Dopamine transporter (1) Endothelin (1) Hypertension (1) NZB/NZWF1 mice (1) Prolactin (1) Rat (1) Sleep deprivation (1) Stress (1) Systemic lupus erythematosus (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2009 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice BJMBR Palma,B.D.; Hipolide,D.C.; Tufik,S.. Sleep disturbances have far-reaching effects on the neuroendocrine and immune systems and may be linked to disease manifestation. Sleep deprivation can accelerate the onset of lupus in NZB/NZWF1 mice, an animal model of severe systemic lupus erythematosus. High prolactin (PRL) concentrations are involved in the pathogenesis of systemic lupus erythematosus in human beings, as well as in NZB/NZWF1 mice. We hypothesized that PRL could be involved in the earlier onset of the disease in sleep-deprived NZB/NZWF1 mice. We also investigated its binding to dopaminergic receptors, since PRL secretion is mainly controlled by dopamine. Female NZB/NZWF1 mice aged 9 weeks were deprived of sleep using the multiple platform method. Blood samples were taken for the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic lupus erythematosus; NZB/NZWF1 mice; Prolactin; Stress; Autoradiography; Dopamine transporter. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300012 Paradoxical sleep deprivation increases plasma endothelin levels BJMBR Palma,B.D.; Gabriel Jr.,A.; Bignotto,M.; Tufik,S.. The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Endothelin; Sleep deprivation; Rat; Hypertension. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100011 Registros recuperados: 2 Primeira ... 1 ... Última

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